NCT01318967

Measurement of Kidney Blood Flow and Oxygen Levels by MRI

MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Wake Forest University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Comparison of renal blood flow measurements by PAH clearance and MRI

Detailed description

The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.

Conditions

• Chronic Kidney Disease

Interventions

Type	Name	Description
DRUG	Furosemide	Renal blood flow is measured after the administration of 20 mg of furosemide during MRI scan only.
OTHER	Placebo

Timeline

• Start date: 2010-10-01
• Primary completion: 2012-06-01
• Completion: 2013-06-01
• First posted: 2011-03-21
• Last updated: 2018-09-07
• Results posted: 2015-04-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study