NCT01318798

Development and Validation of an Enhanced Prediction Score for Postoperative Acute Renal Failure After Liver Resection

Development and Validation of an Enhanced Prediction Score for Post-operative Acute Renal Failure Following Liver Resection

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 549 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

Post-operative acute renal failure is a severe post-operative complication and is associated with high mortality. The enhanced prediction score, including pre-as well as intra-operative predictors accurately predicted ARF following hepatic surgery. This prediction score allows early identification of patients at high risk of ARF and may support decision-making for protective kidney treatment.

Detailed description

To enhance and validate an already pre-existing score accurately predicting post-operative acute renal failure (ARF) after hepatic surgery We will enhance a pre-existing score predicting ARF based on pre-operative as well as intra-operative predictors. Development process: we will identify the strongest predictors of ARF in a multivariable logistic regression model followed by a stepwise backward logistic regression analysis and bootstrapping. Validation process: we will perform an internal validation by calibrating the prediction model as well as by k-fold cross validation (c statistics) and bootstrapping. Additionally, we will calculate the discrimination by the area under the curve (AUC). Decision curve analysis: Furthermore we will perform a decision curve analysis to evaluate the clinical consequences of both prediction scores whether a patient with increased ARF risk would post-operative benefit of a treatment on the ICU.

Conditions

• Acute Renal Failure

Timeline

• Start date: 2010-01-01
• Primary completion: 2012-04-01
• Completion: 2012-04-01
• First posted: 2011-03-18
• Last updated: 2015-02-10

Locations

1 site across 1 country: Switzerland