NCT01318005

Oral Contraceptive (OC) Estrogen Dose and Breast Proliferation

The Effects of Dose and Formulation of Oral Contraceptives (OCs) on Breast-Cell Proliferation: Can the Chemopreventive Effects of OCs on Endometrial and Ovarian Cancer be Extended to Breast Cancer?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to gain a better understanding of the changes that may occur in the breast when a woman uses an oral contraceptive (birth control pill). Some research indicates that women who use birth control pills with lower amounts of estrogen (a hormone in the birth control pill) may have lower breast cell growth than women who use birth control pills with a higher amount of estrogen; this research will examine that in detail.

Conditions

• Oral Contraceptive

Interventions

Type	Name	Description
DRUG	Oral Contraceptive: Ortho-Novum® 1/35	Oral Contraceptive: Ortho-Novum® 1/35, pill, 2-3 mos, daily.
DRUG	Oral Contraceptive: Ovcon® 35	Oral Contraceptive: Ovcon® 35, pill, 2-3 mos, daily.
DRUG	Oral Contraceptive: Microgestin Fe® 1/20	Oral Contraceptive: Microgestin Fe® 1/20, pill, 2-3 mos, daily.

Timeline

• Start date: 2011-02-14
• Primary completion: 2014-06-30
• Completion: 2015-06-30
• First posted: 2011-03-18
• Last updated: 2026-02-17
• Results posted: 2026-02-17

Locations

1 site across 1 country: United States