Trials / Completed
CompletedNCT01315613
Role of ST2 in Acute Pancreatitis
Study of ST2-IL-33 Pathway in Acute Pancreatitis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 44 (actual)
- Sponsor
- Erasme University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Acute pancreatitis is characterized by an inflammatory storm which regulatory pathways are not well known. The IL-1 cytokine family is activated early during acute pancreatitis and secretion of alarmins is speculated during pancreatic necrosis. IL-33 is a member of the IL-1 family, it can act as an alarmin and its receptor, ST2, is known to sequester MyD88 which might regulate the acute pancreatitis inflammatory storm. The aim of this study is to investigate ST2 pathway in human acute pancreatitis and in murine experimental models of acute pancreatitis.
Conditions
Timeline
- Start date
- 2005-01-01
- Primary completion
- 2008-09-01
- Completion
- 2008-09-01
- First posted
- 2011-03-15
- Last updated
- 2011-03-15
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT01315613. Inclusion in this directory is not an endorsement.