NCT01315587

Repetitive Transcranial Magnetic Stimulation and Intermittent Theta Burst (iTBS) in Schizophrenia

A Double-blind Placebo Controlled Trial the Comparison of Effectiveness of Repetitive TMS and iTBS on Negative Symptoms and Cognition in Patients With Schizophrenia

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Tehran · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The pilot studies have showed that theta burst stimulation (TBS) can have the more rapid and durable effects to the apply traditional rTMS protocols. The aim of this study is to investigate the effect of repetitive TMS and theta burst in reduction of negative symptoms and remission of cognitive functioning in patients with schizophrenia. In a randomized, double blind clinical trials, 30 patients with schizophrenia in Razi psychiatric hospital will be assigned to receive repetitive TMS; theta burst, or sham TMS, daily; for 20 sessions. The negative symptoms and cognitive functioning will be assessed before the treatment (pre test) during the treatment (session 10), and after the treatment (post test).QEEG and LORETA apply before and after rTMS in all subjects.

Conditions

• Schizophrenia

Interventions

Type	Name	Description
DEVICE	repetitive Transcranial Magnetic Stimulation (Magstim rapid2 )	* 3 pulses at 50Hz repeated each 200 ms for 2 seconds * 80% MT * 20 days treatment
DEVICE	repetitive Transcranial Magnetic Stimulation (Magstim rapid2)	LDLPFC 110% MT 15 Hz 20 days
DEVICE	repetitive Transcranial Magnetic Stimulation(Magstim rapid2)	Placebo treatment: Sham coil

Timeline

• Start date: 2011-01-01
• Primary completion: 2015-11-01
• Completion: 2017-01-01
• First posted: 2011-03-15
• Last updated: 2015-09-01

Locations

1 site across 1 country: Iran