NCT01314482

Minocycline for the Prevention of Post-operative Intercostal Neuralgia

The Efficacy of Prophylactic Administration of Minocycline in Reducing Chronic Intercostal Neuralgia Post-thoracotomy

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 116 (estimated)
• Sponsor: University of Adelaide · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In about half the patients who have an open chest surgery there is persistent severe pain in the chest. The investigators are examining whether minocycline, a commonly used antibiotic, will prevent pain. Minocycline blocks the activity of immune cells which the investigators believe are responsible for prolonging the pain.

Detailed description

The study is of double-blind placebo controlled parallel groups design in up to 116 patients undergoing elective open thoracotomy. Minocycline 200mg twice daily or matching placebo are given three days before surgery.

Conditions

• Post-operative Intercostal Neuralgia

Interventions

Type	Name	Description
DRUG	Minocycline	200mg bd for 3 days before surgery

Timeline

• Start date: 2010-11-01
• Primary completion: 2013-12-01
• Completion: 2014-02-01
• First posted: 2011-03-14
• Last updated: 2013-02-06

Locations

1 site across 1 country: Australia