NCT01310192

Cancer Localization in the Prostate With F-18 Fluorocholine Positron Emission Tomography

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Queen's Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this project is to develop and evaluate fluorine-18 (F-18) fluorocholine (FCH) positron emission tomography (PET) as an imaging technique that can be used to delineate malignant tumors in the prostate gland. The proposed technique works by measuring the tissue metabolism of FCH, a substrate that is preferentially metabolized by cancer cells due to malignant over-expression of the choline transporter and choline kinase enzyme. The project scope covers a clinical study to recruit men with prostate cancer who have elected treatment by radical prostatectomy surgery. These men will undergo pre-operative PET scanning to measure F-18 FCH uptake in anatomical sextants of the prostate gland. Imaging results will be compared to histopathologic analyses of the prostatectomy specimen to determine the accuracy of F-18 FCH PET for detecting cancerous prostate sextants.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
DEVICE	Fluourine-18 Fluoromethylcholine PET/CT Imaging	Single-dose Study

Timeline

• Start date: 2004-06-01
• Primary completion: 2008-07-01
• Completion: 2008-07-01
• First posted: 2011-03-08
• Last updated: 2022-07-22

Locations

1 site across 1 country: United States