NCT01308320

Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: Female
• Age: 20 Years – 59 Years
• Healthy volunteers: Not accepted

Summary

Fentanyl is expected to suppress tracheal tube-induced cough during emergence from general anaesthesia through binding to its receptors in the brainstem. However, it has not been proven if fentanyl has a complication-free, dose-dependent effect on cough suppression during emergence from sevoflurane anaesthesia. The purpose of this study is to evaluate the relationship between fentanyl doses and cough suppression during emergence from sevoflurane anaesthesia.

Conditions

• Thyroid Neoplasm

Interventions

Type	Name	Description
DRUG	fentanyl citrate	According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.
DRUG	saline	According to the enrolled group, certain dose of saline is intravenously administered by bolus just after sevoflurane discontinuation.

Timeline

• Start date: 2010-02-01
• Primary completion: 2010-07-01
• Completion: 2010-07-01
• First posted: 2011-03-04
• Last updated: 2011-03-04

Locations

1 site across 1 country: South Korea