Trials / Completed
CompletedNCT01307306
Glucose Control in Severely Burned Patients
Glucose Control in Severely Burned Patients: Mechanisms and Therapeutic Potential
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 45 (actual)
- Sponsor
- Sunnybrook Health Sciences Centre · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
The central aim of this application is to determine whether improved outcomes with tight euglycemic control are due to insulin-specific responses. The investigators hypothesize that improving insulin resistance will lead to decreased inflammatory and hypermetabolic responses, as well as restored glucose metabolism, and so result in improved clinical outcome of severely burned patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Humulin R | Humulin R (U-100) will be given i.v. The dose given will be adjusted in order to achieve a blood glucose level of 130-140 mg/dl. |
| DRUG | Metformin | Metformin 850 mg q. 8 hours will be given to decrease blood glucose to 130-140 mg/dl. |
Timeline
- Start date
- 2011-03-01
- Primary completion
- 2018-03-01
- Completion
- 2018-03-01
- First posted
- 2011-03-02
- Last updated
- 2022-03-28
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT01307306. Inclusion in this directory is not an endorsement.