NCT01306773

Convalescent Plasma Treatment in Severe 2009 H1N1 Infection

Convalescent Plasma Treatment in Patients With Severe 2009 H1N1 Infection: a Prospective Cohort Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: The University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Treatment of severe 2009 H1N1 infection with convalescent plasma will reduce mortality.

Detailed description

Patients presented with severe 2009 H1N1 infection responded poorly to antiviral agents. Meta-analysis of reports from 1918 H1N1 pandemic suggested that convalescent plasma might be an effective treatment option for patients with severe 2009 H1N1 infection.

Conditions

• Influenza A

Interventions

Type	Name	Description
DRUG	H1N1 convalescent plasma and oseltamivir	Oseltamivir 75mg bid orally during ICU hospitalization + 500mL convalescent plasma containing \>= 1:160 of neutralizing antibody to Pandemic influenza A H1N1
DRUG	Oral Oseltamivir alone	Oral Oseltamivir 75mg bid during ICU hospitalization

Timeline

• Start date: 2009-12-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2011-03-02
• Last updated: 2011-03-02

Locations

1 site across 1 country: China