NCT01306578

Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS)

Comparison of Intravenous Immunoglobulin and Plasma Exchange in Treatment of Mechanically Ventilated Children With Guillain Barre Syndrome. A Randomized Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: Mansoura University Children Hospital · Academic / Other
• Sex: All
• Age: 1 Month – 18 Months
• Healthy volunteers: Not accepted

Summary

Comparing whether intravenous immune globulin or plasma exchange is superior in treating mechanically ventilated children with Guillain Barre syndrome.

Detailed description

Children with Guillain Barre syndrome (GBS) admitted to PICU at Mansoura University Children Hospital, Mansoura, Egypt with the need for mechanical ventilation were prospectively enrolled in the study. Cases were diagnosed according to clinical criteria. The decisions to initiate, wean and terminate mechanical ventilation were made independently by the attending consultant in accordance with the unit guidelines. Outcome variables measured were duration of mechanical ventilation, length of PICU stay and ability to walk unaided 4 weeks after PICU discharge.

Conditions

• Guillain Barre Syndrome

Interventions

Type	Name	Description
DRUG	IVIG	Intravenous Immune Globulin at a dose 0f 0.4 g/kg/day for 5 consecutive days
PROCEDURE	Plasma Exchange	Five sessions of plasma exchange, single plasma volume each, for 5 consecutive days

Timeline

• Start date: 2007-01-01
• Primary completion: 2009-12-01
• Completion: 2010-02-01
• First posted: 2011-03-02
• Last updated: 2011-03-02

Locations

1 site across 1 country: Egypt