NCT01299753

Catecholamine Blockade Post-burn

Clinical and Molecular Effects of Catecholamine Blockade Post-burn

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Sunnybrook Health Sciences Centre · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Severe burn is associated with a wide array of stress, metabolic, and physiologic processes in an attempt to restore homeostasis. The catecholamine induced stress response following severe burns is particularly exaggerated and manifests detrimentally as inflammation, insulin resistance, hypermetabolism, and associated profound protein catabolism. The investigators hypothesize that catecholamine blockade will lead to restored IR signaling and result in improved post-burn morbidity. The investigators will further determine the molecular mechanisms mediating these effects.

Conditions

• Burns

Interventions

Type	Name	Description
DRUG	placebo	identically packed placebo
DRUG	propranolol	20-40 mg q6-8h

Timeline

• Start date: 2011-02-01
• Primary completion: 2022-12-31
• Completion: 2023-12-31
• First posted: 2011-02-18
• Last updated: 2022-03-28

Locations

1 site across 1 country: Canada