NCT01297907

Bronchial Hyperreactivity in Children With Crohn Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 47 (actual)
• Sponsor: Rambam Health Care Campus · Academic / Other
• Sex: All
• Age: 6 Years – 25 Years
• Healthy volunteers: Accepted

Summary

Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to determine the frequency of bronchial hyperreactivity in pediatric patients followed and treated for Crohn disease. Methods: Twenty-three children with Crohn disease completed a questionnaire, followed by spirometry, Methacholine Challenge Test (MCT) and determination of Fractional Exhaled NO (FENO). The control group included patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT).

Conditions

• Crohn's Disease

Interventions

Type	Name	Description
OTHER	Methacholine Challenge Test	Methacholine challenge test to evaluate airway hyperreactivity
OTHER	Fractional Exhaled NO (FENO)	Fractional Exhaled NO to evaluate eosinophilic inflammation
OTHER	Blood Test	Blood Tests (Eosinophil Count)
OTHER	PCDAI	Clinical Evaluation for Pediatric Crohn's Disease Activity Index (PCDAI)

Timeline

• Start date: 2008-05-01
• Primary completion: 2009-12-01
• Completion: 2009-12-01
• First posted: 2011-02-17
• Last updated: 2011-02-17

Locations

1 site across 1 country: Israel