NCT01297894

Colistin Versus Colistin Plus Fosfomycin for Infections Caused by MDR Acinetobacter Baumannii

Colistin Plus Fosfomycin in Multi-Drug Resistant Acinetobacter Baumannii

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 92 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In Siriraj Hospital, colistin alone for treatment of MDR A. baumannii contributed to mortality 45% Fosfomycin is an antimicrobial which has activity against gram-negative bacterial including MDR A. baumannii In this study, we compare the clinical and microbiologicalresponse of colistin alone versus colistin plus fosfomycin in treatment of A. baumannii infected patients

Detailed description

Inclusion criteria * Age\> 18 years * Hospitalized to Siriraj Hospital * Infected caused by A. baumannii * Need Colistin treatment Exclusion criteria * Pregnancy or Lactating mother * Colistin or Fosfomycin Allergy * Patients who have severe abnormal renal or liver function

Conditions

• Drug Safety

Interventions

Type	Name	Description
DRUG	colistin	Colistimethate sodium 2.5-5mg/kg of colistin base
DRUG	colistin plus fosfomycin	colitimethate sodium 2.5-5mg/kg iv plus fosfomycin 2gm iv every 12 hours

Timeline

• Start date: 2010-06-01
• Primary completion: 2012-05-01
• Completion: 2012-05-01
• First posted: 2011-02-17
• Last updated: 2011-12-29

Locations

1 site across 1 country: Thailand