NCT01296334

Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine

Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine Following an Experimental Inflammatory Injury in Volunteers.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: mads u werner · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia). In the present study we investigate primary and secondary hyperalgesia in healthy volunteers following an experimental first degree burn injury. The objectives are: * to compare analgesic and anti-hyperalgesic effects of two opioids (morphine and buprenorphine). * to investigate if these effects are related to the volunteers individual pain sensitivity

Detailed description

Please refer to: Ravn P, Secher EL, Skram U, Therkildsen T, Christrup LL, Werner MU (2013) Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study. J Pain Res 6: 23-38. 10.2147/JPR.S36827 \[doi\];jpr-6-023 \[pii\].

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	morphine LO	intravenous infusion, 10 mg, once, 4 hours
DRUG	Morphine Hi	intravenous infusion, 20 mg, once, 4 hours
DRUG	Buprenorphine LO	intravenous infusion, 0.3 mg, once, 4 hours
DRUG	Buprenorphine Hi	intravenous infusion, 0.6 mg, once, 4 hours
OTHER	saline	intravenous infusion, 0.9% saline, once, 4 hours

Timeline

• Start date: 2011-02-01
• Primary completion: 2011-09-01
• Completion: 2011-10-01
• First posted: 2011-02-15
• Last updated: 2016-11-28

Locations

1 site across 1 country: Denmark