Trials / Completed
CompletedNCT01295892
Chronic Effects of Estrogen in Microcirculation
Chronic Effects of Estrogen in Microcirculation and Insulin Resistance in Postmenopausal Obese Women
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 44 (actual)
- Sponsor
- Rio de Janeiro State University · Academic / Other
- Sex
- Female
- Age
- 48 Years – 55 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to evaluate the chronic effects of estrogen on microcirculation, inflammatory biomarkers, hormonal status, plasma viscosity and biochemical tests in postmenopausal obese women after three months of follow-up intervention.
Detailed description
Estrogens exert pleiotropic actions on the cardiovascular system through binding to estrogen receptors. Traditionally, estrogen receptors have been recognized as transcription factors regulating the expression of target genes, however, numerous studies have revealed rapid actions of estrogen in different systems, so-called 'extranuclear actions'. At this level, estrogen triggers rapid vasodilatation, exerts anti-inflammatory effects, regulates vascular cell growth and migration, and confers protection to cardiomyocytes. Our aims are to investigate estrogen´s chronic effects on microcirculation. The study will assess the potential benefits of estrogens on: chronic low-grade inflammation, metabolic profile, microcirculation and blood rheology. Postmenopausal obese women will be randomly submitted to estrogen (transdermal 17-β-estradiol 1mg/day) or placebo therapy during three months in a double-blind fashion. At baseline and after intervention, nailfold videocapillaroscopy, laser-Doppler flowmetry and venous occlusion plethysmography, inflammatory biomarkers, hormonal status, metabolic profile, plasma viscosity and anthropometrical measures will be assessed in all subjects.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Estrogen | transdermal 17-β-estradiol 1mg/day during three months |
Timeline
- Start date
- 2011-12-01
- Primary completion
- 2013-03-01
- Completion
- 2013-04-01
- First posted
- 2011-02-15
- Last updated
- 2013-04-18
Locations
1 site across 1 country: Brazil
Source: ClinicalTrials.gov record NCT01295892. Inclusion in this directory is not an endorsement.