NCT01293058

Randomized Trial of Intranasal Versus Intravenous Naloxone in Level of Consciousness in Suspected Opioid Overdose

Study of Routs of Naloxone Administration for Opioid Overdosed Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Isfahan University of Medical Sciences · Academic / Other
• Sex: All
• Age: 15 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine which route of administration is better for treatment of opioid overdosed patients

Detailed description

In intravenous drug abusers (IDUs), as a result of previous intravenous substance abuse, the predictable difficult cannulate exist and cause the delay administration of antidote therapy. Additionally, IDUs are also at increased risk of carrying blood borne infections that could be transmitted to healthcare workers through needle stick injuries. The investigators aimed to compare intranasal administration of naloxone with intravenous route.

Conditions

• Morphinan Opioid Overdose

Interventions

Type	Name	Description
DRUG	Intranasal naloxone	spray naloxone, 0.4 mg/ each 4 minutes till increasing patient level of consciousness
DRUG	Intravenous	Amp naloxone, 0.4 mg / each 4 minutes till increasing patient level of consciousness

Timeline

• Start date: 2007-03-01
• Primary completion: 2007-06-01
• Completion: 2007-06-01
• First posted: 2011-02-10
• Last updated: 2011-02-10

Locations

1 site across 1 country: Iran