NCT01292772

The Effects of Radiation in Reconstructed Breasts

The Effects of Radiation Therapy on the Reconstructed Breast: An Evaluation Using MR Imaging

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 12 (actual)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: Female
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to use LR imaging to evaluate the effects of adjuvant radiation therapy on reconstructed breasts.

Detailed description

Immediate breast reconstruction following mastectomy has become an increasingly popular and accepted treatment option among breast cancer patients. This change in practice has resulted in a significant number of patients who undergo radiation therapy after breast reconstruction. Following irradiation, the reconstructed breast often experiences fibrotic contracture, volume loss, altered pigmentation, or some combination thereof, producing an asymmetric and aesthetically compromised result. The effects of radiation on reconstructed breasts as well as the implications that such changes have for timing of reconstructive surgery, post-operative management and surveillance imaging are topics of growing importance in plastic surgery, radiology and surgical oncology.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
PROCEDURE	contract-enhanced MRI	Patients will have contrast-enhanced MRI of the breasts.
RADIATION	Unilateral Adjuvant Radiation Therapy	The study group will consist breasts receiving post-operative radiation, and the control group will consist of the patient's breasts on the non-radiated side. In this way, patients will act as their own control.

Timeline

• Start date: 2010-12-01
• Primary completion: 2016-12-01
• Completion: 2019-05-05
• First posted: 2011-02-10
• Last updated: 2020-04-08

Locations

1 site across 1 country: United States