NCT01291277

Time Interval for Endoscopic Variceal Ligation

Appropriate Time Interval for Repeat Sessions of Endoscopic Ligation for the Eradication of Esophageal Varices

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with liver disease frequently present to the hospital with bleeding from dilated veins in their foodpipe (called esophageal varices). The current standard of care is to perform endoscopic variceal ligation (placing rubber bands around the varices through an endoscope)in patients presenting with bleeding varices. Patients generally receive ligation at the time they come in with bleeding and then return at regular intervals to have repeat ligation in order to eradicate the varices. However there have been no studies to determine the appropriate intervals for esophageal variceal ligation until eradication. We will conduct a randomized comparison of 1-week vs. 2-week intervals for esophageal ligation in patients that have presented with bleeding varices. Our hypothesis is that one-week ligation will achieve more rapid eradication than the two-week interval with a greater proportion of patients achieving variceal eradication at 4 weeks after the index bleeding episode.

Conditions

• Variceal Bleeding

Interventions

Type	Name	Description
DEVICE	Endoscopic Variceal Ligation	Ligation of esophageal varices

Timeline

• Start date: 2008-08-01
• Primary completion: 2015-09-01
• Completion: 2015-12-01
• First posted: 2011-02-08
• Last updated: 2017-02-13
• Results posted: 2016-12-26

Locations

1 site across 1 country: United States