NCT01291212

Efficacy of Luteinizing Hormone (LH) Activity in Low Responder Patients With Transdermal Testosterone

Efficacy of LH Activity in Low Responder Patients With Transdermal Testosterone: a Randomised Controlled Study.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 104 (actual)
• Sponsor: Hospital Clinic of Barcelona · Academic / Other
• Sex: Female
• Age: 18 Years – 41 Years
• Healthy volunteers: Accepted

Summary

The investigators have previously demonstrated the utility of transdermal testosterone in in vitro fertilization (IVF) low responder patients. Now, the investigators want to evaluate the efficacy of luteinizing hormone (LH) activity added to recombinant follicular stimulating hormone (FSHr) during ovarian stimulation in these patients.

Detailed description

Studies in macaques have indicated that androgens have some synergistic effects with follicular stimulating hormone (FSH) on folliculogenesis. Our previous clinical studies demonstrated the usefulness of pretreatment with transdermal testosterone in low-responder IVF patients. There is controversy on the usefulness of recombinant luteinizing hormone (LHr) added to FSHr in ovarian stimulation of low responder patients. Thus, our present study has been designed to compare ovarian stimulation with FSHr alone versus LHr added to FSHr when transdermal testosterone pretreatment is used.

Conditions

• Other Complications Associated With Artificial Fertilization

Interventions

Type	Name	Description
DRUG	Testosterone and FSHr-LHr	75U of LHr added to FSHr ovarian stimulation in IVF, when testosterone was used to improve the ovarian response
DRUG	testosterone and FSHr alone	FSHr alone used in ovarian stimulation in IVF, when testosterone was used to improve the ovarian response

Timeline

• Start date: 2011-01-01
• Primary completion: 2011-06-01
• Completion: 2011-09-01
• First posted: 2011-02-08
• Last updated: 2011-02-08

Locations

1 site across 1 country: Spain