NCT01291030

The Impact of Magnesium Supplementation on Insulin Resistance and Secretion in Renal Transplant Recipients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hypomagnesemia is common in renal transplant recipients and is mainly because of enhanced renal magnesium wasting, caused by immunosuppressive drugs (calcineurin inhibitors). Glucose metabolism disorders, including insulin resistance and decreased insulin secretion, are also prevalent post-transplantation and often precede the development of diabetes. As magnesium supplementation has been demonstrated to increase insulin sensitivity in both diabetic and non-diabetic patients, its potential therapeutic supplementation (post-transplantation) deserves further examination. The hypothesis is that magnesium supplementation in renal transplant recipients exerts a beneficial effect on insulin resistance and/or secretion.

Conditions

• Glucose Metabolism
• Renal Transplantation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	magnesium supplementation	The supplementation starts with 450 mg of magnesium oxide daily, up to a maximum of 3 times 450 mg daily, while aiming at a serum magnesium level of \> 1,9 mg/dl.

Timeline

• Start date: 2011-01-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2011-02-07
• Last updated: 2017-01-18

Locations

2 sites across 1 country: Belgium