Trials / Completed
CompletedNCT01289769
The Effect of Dexmedetomidine on Hemodynamic Response During Double Lumen Endotracheal Intubation
The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances During Double Lumen Endotracheal Intubation. A Double-blinded, Randomized, Placebo-Controlled Trial.
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Chiang Mai University · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to evaluate the effect of dexmedetomidine on hemodynamic responses during laryngoscopy and double lumen endotracheal intubation and assess the adverse effect related to complications of dexmedetomidine.
Detailed description
The cardiovascular responses to laryngoscopy and tracheal intubation are mediated by both sympathetic and parasympathetic nervous system. The hemodynamic responses resulting from sympathetic nervous system stimulation are tachycardia, cardiac arrhythmias, hypertension, increased intraocular pressure, increased intracranial pressure, bronchospasm and myocardial ischemia. Tachycardia is one of the major predictor of intraoperative myocardial ischemia and causes an imbalance of myocardial oxygen supply and demand. Although hemodynamic responses to laryngoscopy and intubation is transient, these effect may be harmful to patients suffering from myocardial and cerebrovascular diseases. The placement of double lumen endotracheal tube may produce similar or greater pressor response than endotracheal tube because of larger sizes and greater carinal stimulation.
Conditions
- Intubation Complication
- Tracheal Intubation Morbidity
- Anesthesia Intubation Complication
- Hypertension
- High Blood Pressure
- Tachycardia
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Dexmedetomidine | dexmedetomidine 0.7 microgram per kilogram in saline 20 ml given within 10 minutes before intubation |
| DRUG | Placebo | normal saline 20 ml( the same volume as dexmedetomidine) giving within 10 minutes. |
Timeline
- Start date
- 2011-03-01
- Primary completion
- 2011-12-01
- Completion
- 2011-12-01
- First posted
- 2011-02-04
- Last updated
- 2011-12-15
Locations
1 site across 1 country: Thailand
Source: ClinicalTrials.gov record NCT01289769. Inclusion in this directory is not an endorsement.