Trials / Completed
CompletedNCT01289548
Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
Effect of Lower Limb Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 120 (actual)
- Sponsor
- Huazhong University of Science and Technology · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The purpose of this study was to investigate whether lower limb ischaemic preconditioning can improve renal function in patients undergoing living donor kidney transplantation
Detailed description
Ischemia reperfusion injury (IRI) induced renal failure after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. To reduce the adverse effects of IRI after organ transplantation various strategies aimed at the different pathophysiological processes of IRI have been investigated. Remote ischemic preconditioning (RIPC) is one such strategy where brief IRI of one organ protects other organs from sustained IRI. Many studies have shown that RIPC protects heart, muscle flaps, stomach, liver, lungs, and kidneys from IRI. RIPC of the limb with a tourniquet is a safe and convenient method of preconditioning organs against IRI. However, the efficacy of RIPC in patients undergoing living donor kidney transplantation need to be established and mechanism of early and late RIPC, such as whether the donor should undergo remote preconditioning or the recipient, need to be investigated.
Conditions
- Kidney Diseases
- Kidney Failure, Chronic
- Kidney Failure
- Renal Insufficiency
- Renal Insufficiency, Chronic
- Urologic Diseases
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | remote ischaemic preconditioning | Remote ischaemic preconditioning consisted of three 5-min cycles of left lower limb ischaemia, which was induced by an automated cuff-inflator placed on the left lower limb and inflated to 300 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated. |
Timeline
- Start date
- 2010-05-01
- Primary completion
- 2011-11-01
- Completion
- 2012-01-01
- First posted
- 2011-02-03
- Last updated
- 2013-09-10
- Results posted
- 2013-09-10
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT01289548. Inclusion in this directory is not an endorsement.