NCT01288547

Effects of Theobromine and Caffeine on Mood, Cognition and Blood Pressure

Temporal Change of Mood and Cognition in Healthy Subjects After Consumption of Theobromine and/ or Caffeine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Unilever R&D · Industry
• Sex: Female
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study was to measure potential mood, cognition and blood pressure effects of theobromine and caffeine in healthy women

Detailed description

Background Previous research has shown that naturally occurring chocolate ingredients theobromine and caffeine have positive effects on mood. Objectives: To assess mood and cognition in adult subjects after the consumption of capsules filled with 1. placebo, 2. theobromine alone, 3. caffeine alone or, 4. theobromine and caffeine combined together. Study design: Double-blind, placebo-controlled, randomized, cross-over design, with a 1 week washout period in between. During the 4 weeks intervention period, once a week one of the 4 types of test products were consumed with 250ml of water in a randomized order; 1. placebo capsules 2. theobromine capsules (700 mg), 3. caffeine capsules (120 mg), 4. mix of theobromine (700 mg) and caffeine (120 mg). Twenty-four healthy female subjects (and 4 reserve subjects) were recruited for a four week intervention period in total with every week a 4 hrs measurement day and one of the interventions. Primary parameters: mood (via a Bond-Lader/ caffeine visual analogue questionnaire), cognition (Digit Symbol substitution) Secondary parameters: blood pressure

Conditions

• Mood

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	theobromine	700 mg theobromine in gelatin capsules given one time only
DIETARY_SUPPLEMENT	Caffeine	120 mg caffeine in capsules given one time only
DIETARY_SUPPLEMENT	caffeine + theobromine	120 mg caffeine and 700 mg theobromine in capsules given one time only
DIETARY_SUPPLEMENT	placebo	cellulose in capsules given one time only

Timeline

• Start date: 2008-05-01
• Primary completion: 2008-06-01
• Completion: 2008-07-01
• First posted: 2011-02-02
• Last updated: 2012-02-23

Locations

1 site across 1 country: Netherlands