NCT01286493

Immune Response After Booster Vaccination in HIV - Infected Patients Who Received Rabies Primary Vaccination

Immune Response After Booster Vaccination in HIV - Infected Patients Who Ever Received Rabies Primary Vaccination

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Queen Saovabha Memorial Institute · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Booster rabies vaccination in HIV - infected patients who have ever received rabies primary vaccination could improve their immune response to this kind of vaccine.

Detailed description

The investigators have learned from the previous studies that some HIV-infected patients especially those with low CD4+ T-lymphocyte count had poor antibody response to rabies vaccination. Because of the role of the memory B cell, the investigators hypothesized that primary rabies immunization in HIV-infected patients could rise rapid anamnestic antibody response to ones after booster vaccination in case of re-exposure of rabies occur despite of their immunocompromised state.

Conditions

• HIV
• Rabies

Interventions

Type	Name	Description
BIOLOGICAL	rabies vaccines on day 0 and 3	All subjects would receive conventional intramuscular booster rabies vaccination on day 0 and 3. Their blood would be drawn for rabies neutralizing antibody on day 0,7,14,30,90,180,360

Timeline

• Start date: 2011-02-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2011-01-31
• Last updated: 2015-11-18
• Results posted: 2014-06-04

Locations

1 site across 1 country: Thailand