NCT01280864

MAPP Investigation of Pelvic Floor-Brain Neurobiologic Axis in IC/IBS and IBS

Investigation of Pelvic Floor-Brain Neurobiologic Axis in IC/IBS and IBS

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 36 (actual)
• Sponsor: Augusta University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Hypotheses: 1. The bidirectional signaling between the cortex, and the pelvic floor/gut is deranged in patients with IC and in IBS. Consequently, they will demonstrate hyperexcitability of the pelvic floor/brain axis as evidenced by shorter latencies and increased amplitudes for both the afferent anorectal-cortical evoked potentials and efferent cortically-induced (magnetic) anorectal motor evoked potentials. 2. Unlike patients with IC alone, patients with IBS will also demonstrate anorectal visceral hypersensitivity and anorectal sensory-motor dysfunction.

Conditions

• Interstitial Cystitis
• Irritable Bowel Syndrome

Timeline

• Start date: 2010-03-01
• Primary completion: 2011-08-01
• Completion: 2011-08-01
• First posted: 2011-01-21
• Last updated: 2018-07-23

Locations

1 site across 1 country: United States