NCT01280292

Central Hypothyroidism, a Novel Laboratory Measurement

Central Hypothyroidism,a New Laboratory Approach for Hormone Measurement

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Sheba Medical Center · Other Government
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Medical management of central hypothyroidism is controversial due to lack of reference for evaluation of pituitary negative feedback. Therefore, titration of medical treatment is based on T4 levels, measured with variable laboratory methods. Patients who have central hypothyroidism usually have concomitant deficiencies in other pituitary hormones for which they need replacement therapy such as steroids, testosterone and growth hormone. This combined hormone deficiency makes clinical and laboratory evaluation challenging among these patients. Symptomatically, central hypothyroidism is relatively mild and lack non-specific and it might be overlooked due to other hormonal deficiencies. Replacement therapy for central hypothyroidism is titrated by arbitrary target free T4 levels of above 50th percentile of normal. The goal of our study is to compare the standard results from well known measure methods to a new method for measuring Ft4 using Liquid chromatography - tandem mass spectrometry.

Conditions

• Central Hypothyroidism

Interventions

Type	Name	Description
DRUG	Eltroxin	Eltroxin dosage titration according to free T4 measurement every 3 months

Timeline

• Start date: 2011-02-01
• Primary completion: 2013-02-01
• Completion: 2013-07-01
• First posted: 2011-01-20
• Last updated: 2011-02-03