NCT01280149

Reduction of IgE Antibody in Human Allergic Subjects

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether a neuropeptide, substance P, when injected along with an allergen, such as ragweed, can reduce allergic reactivity.

Detailed description

Allergic Rhinitis (Hay fever) affects many children and adults and is a risk factor for development of asthma. This study utilizes the neurotransmitter, substance P, a small molecule which is present in nerve endings, the brain, skin, lungs and the gastrointestinal tract. Subjects will receive substance P and a low dosage of an allergen, such as ragweed in an attempt to reduce allergic reactivity.

Conditions

• Seasonal Allergic Rhinitis

Interventions

Type	Name	Description
BIOLOGICAL	substance P	injections of substance P and low dose allergen or placebo
BIOLOGICAL	substance P injections	injections of substance P for 8 weeks

Timeline

• Start date: 2011-01-01
• Primary completion: 2017-06-20
• Completion: 2017-06-20
• First posted: 2011-01-20
• Last updated: 2018-08-21

Locations

1 site across 1 country: United States