NCT01279928

Detection of Vascular Injury in Diabetes Through Eye and Nailfold Data (DIVIDEND) - A Pilot Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 26 (actual)
• Sponsor: John Hunter Hospital · Other Government
• Sex: All
• Age: 8 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

This project aimed to explore novel methods of detecting small blood vessel disease in a paediatric population with type 1 diabetes mellitus. To do this the techniques of Nailfold capillaroscopy, laser Doppler flowmetry, retinal (eye) vessel analysis and 24-hr Ambulatory Blood Pressure Monitoring were used. Each of these techniques investigated different areas of small blood vessels around the body. It was hypothesized that in a paediatric population with type 1 diabetes mellitus the novel investigations would be associated with small blood vessel disease and that widespread changes to these blood vessels would be detected through associations between the different novel investigations.

Conditions

• Type 1 Diabetes Mellitus

Interventions

Type	Name	Description
PROCEDURE	Video Nailfold Capillaroscopy	Single session of video Nailfold Capillaroscopy wit KKK technology
DEVICE	Ambulatory 24 hr Blood Pressure Monitoring	24 hr upper arm cuff measurement of Blood Pressure
PROCEDURE	Fundoscopy of eyes	examination of microvascular health of eye with the use of opthalmoscope
PROCEDURE	Laser Doppler Flowmetry	Examination of vascular flow

Timeline

• Start date: 2010-03-01
• Primary completion: 2010-09-01
• Completion: 2010-10-01
• First posted: 2011-01-20
• Last updated: 2011-01-25

Locations

1 site across 1 country: Australia