NCT01278732

Central Blood Pressure Over 24 Hours (ABPM) and Left Ventricular Mass

Central Blood Pressure Over 24 Hours (ABPM) and Left Ventricular Mas

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 350 (actual)
• Sponsor: Klinikum Wels-Grieskirchen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The investigators aim to investigate whether central systolic blood pressure, as measured during regular 24 hour ambulatory blood pressure monitoring (ABPM), is a better predictor of left ventricular mass than peripheral systolic blood pressure during ABPM.

Detailed description

It seems obvious that central blood pressures are pathophysiologically more relevant than peripheral blood pressures for the pathogenesis of cardiovascular disease: it is central systolic pressure (cSBP) against the heart ejects (afterload), and it is central pulse pressure (cPP) that distends the large elastic arteries. Indeed, cSBP and cPP have been associated more closely with left ventricular hypertrophy and carotid atherosclerosis as markers of hypertensive end-organ damage than brachial pressures in various populations. However, in these studies office blood pressure measurements have been used. As ABPM measurements per se show a closer association with hypertensive end-organ damage than office measurements, and as the investigators have recently developed and validated a novel algorithm (ARCSolver) to calculate central blood pressures from peripheral waveforms, the investigators speculate that cSBP measured during ABPM may be the best predictor of left ventricular mass.

Conditions

• Suspected Arterial Hypertension

Interventions

Type	Name	Description
OTHER	no intervention performed	no intervention is performed

Timeline

• Start date: 2011-01-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2011-01-19
• Last updated: 2015-04-03

Locations

10 sites across 7 countries: Austria, Germany, Greece, Italy, Spain, Switzerland, United Kingdom