NCT01278368

Effect Of Preoperative Chemotherapy On Short-Term Outcome After Pancreatic Resection

PREOPERATIVE CHEMOTHERAPY DOES NOT ADVERSELY AFFECT SHORT-TERM OUTCOME AFTER PANCREATIC RESECTION.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Università Vita-Salute San Raffaele · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

No comparative trial investigating the effect of preoperative chemotherapy for locally advanced pancreatic cancer on short-term postoperative outcome has been published so far. The aim of the present study is to assess the potential impact of preoperative chemotherapy on short-term postoperative outcome after pancreatic resection in a case-matched series of cancer patients.

Detailed description

Between 2003 and 2011, patients with locally advanced (stage III) pancreatic cancer who were treated with preoperative chemotherapy (PCHT) underwent surgical resection. Each patient was matched with the closest two patients with pancreatic cancer ( control group ) selected from our prospective electronic database who met the following match criteria: age (+/- 3 years), gender, ASA score, type of resection, pancreatic duct diameter (+/- 1 mm), and tumour size (+/- 5 mm).

Conditions

• Locally Advanced Pancreatic Adenocarcinoma

Interventions

Type	Name	Description
PROCEDURE	Pancreatic resection after preoperative chemotherapy	Pancreatic resection after preoperative chemotherapy
PROCEDURE	Pancreatic resection	Pancreatic resection

Timeline

• Start date: 2003-01-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2011-01-17
• Last updated: 2012-12-24

Locations

1 site across 1 country: Italy