NCT01278212

Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer

A Phase II Study of Accelerated Hypofractionated Radiotherapy (AHF-RT) After Breast Conserving Surgery (BCS) in Medically Underserved Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 158 (actual)
• Sponsor: University of Louisville · Academic / Other
• Sex: Female
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to explore the safety, effectiveness, quality of life, and cost effectiveness of accelerated hypofractionated radiotherapy (AHF-RT) as treatment after lumpectomy in patients with early stage breast cancer.

Detailed description

The traditional radiation treatment schedule for patients who have had a lumpectomy for early stage breast cancer is 15 to 30 treatments delivered once a day for 3 to 6 weeks. This treatment schedule can be inconvenient and costly for elderly, rural, uninsured, and minority patients. This study will evaluate a new radiation treatment schedule called whole-breast accelerated hypofractionated radiotherapy (AHF-RT). AHF-RT delivers higher doses of radiation in fewer treatments than traditional radiation therapy. The AHF-RT treatment course is completed with 5 radiation treatments delivered once a week for 5 weeks. The purpose of this study is to determine if accelerated hypofractionated radiotherapy (AHF-RT) is a safe, effective, more convenient, and less costly alternative to traditional radiation that will offer the same chance of cure with no additional side effects.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
RADIATION	accelerated hypofractionated radiotherapy (AHF-RT)	30 Gy in 5 fractions once a week for 5 weeks, followed by optional boost of 10-16 Gy

Timeline

• Start date: 2011-01-01
• Primary completion: 2021-01-27
• Completion: 2021-01-27
• First posted: 2011-01-17
• Last updated: 2024-02-22
• Results posted: 2024-02-22

Locations

1 site across 1 country: United States