NCT01277159

Duration of Analgesia After Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (actual)
• Sponsor: Hospital for Special Surgery, New York · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Patients scheduled to go home after ankle surgery at HSS typically receive a sciatic nerve block in the popliteal fossa and oral analgesic tablets (such as Percocet). Popliteal fossa nerve blockade has reduced pain for these patients (YaDeau et al, Anesth Analg 2008;106:1916-20), but unfortunately the patients still often experience moderate to severe pain after the block wears off. The investigators wish to study two additives that may prolong the period of analgesia provided by the nerve block. The additives will be studied in the context of a standardized postoperative multimodal analgesic pathway. Primary outcome: Does adding dexamethasone and / or buprenorphine prolong the analgesia provided by a popliteal fossa nerve block?

Conditions

• Patients Undergoing Ankle Surgery

Interventions

Type	Name	Description
DRUG	A. Control Nerve Block. IV Dexamethasone (4 mg).	A. Control Nerve Block. IV Dexamethasone (4 mg).
DRUG	B. Nerve Block with Dexamethasone (4 mg). IV saline.	B. Nerve Block with Dexamethasone (4 mg). IV saline.
DRUG	C. Control Nerve Block. IV Dexamethasone (4 mg). IV Buprenorphine (0.3 mg)	C. Control Nerve Block. IV Dexamethasone (4 mg). IV Buprenorphine (0.3 mg)
DRUG	D. Nerve Block with Buprenorphine (0.3 mg). IV Dexamethasone (4 mg).	D. Nerve Block with Buprenorphine (0.3 mg). IV Dexamethasone (4 mg).
DRUG	E. Nerve Block with Dexamethasone (4 mg) / block Buprenorphine (0.3 mg).	E. Nerve Block with Dexamethasone (4 mg) / block Buprenorphine (0.3 mg). IV saline.

Timeline

• Start date: 2010-10-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2011-01-14
• Last updated: 2022-04-14
• Results posted: 2017-08-31

Locations

1 site across 1 country: United States