NCT01276743

Study of PTPN22 C1858T Polymorphism in Children and Adolescents of Greek Origin With T1DM

Study of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22) C1858T Polymorphism in Children and Adolescents of Greek Origin With Type 1 Diabetes Mellitus (T1DM)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Aristotle University Of Thessaloniki · Academic / Other
• Sex: All
• Age: 3 Years – 18 Years
• Healthy volunteers: Accepted

Summary

The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes a lymphoid-specific phosphatase (LYP) which is an important downregulatory factor of T cell activation. A PTPN22 polymorphism, C1858T, was found associated with T1DM in different Caucasian populations. In this observational case-control study, we aimed at confirming the role of PTPN22, C1858T polymorphism in T1DM predisposition in a Greek population.

Conditions

• Type 1 Diabetes Mellitus

Timeline

• Start date: 2010-02-01
• Primary completion: 2011-07-01
• Completion: 2013-02-01
• First posted: 2011-01-13
• Last updated: 2014-02-28

Locations

1 site across 1 country: Greece