NCT01276691

Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Illinois at Urbana-Champaign · Academic / Other
• Sex: Male
• Age: 40 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The investigators hypothesize that 1. an acute treatment of low-dose aspirin will lead to a) decreased resting platelet activation, platelet aggregation, and clotting potential, b) increased fibrinolytic potential following fire fighting, c) no significant effect on endothelial function or arterial stiffness versus the placebo condition. 2. chronic treatment with low-dose aspirin will lead to a) decreased resting and fire fighting induced platelet activation, platelet aggregation, clotting potential, b) increased fibrinolytic potential, and c) increased endothelial function and decreased arterial stiffness in response to live fire fighting versus the placebo condition. 3. short-term fire fighting activity will result in: a) a reduction in arterial function (reduced endothelial function, increased augmentation index and an attenuated arterial stiffness response); b) a disruption in hemostasis that is characterized by an increase in platelet number and function, an increased coagulatory potential and altered fibrinolytic potential; and c) an elevation in procoagulatory cytokines, systemic inflammation, monokine chemoattractant protein, and matrix metalloproteinases.

Conditions

• Cardiovascular Risk Factor
• C.Medical Procedure; Vascular, Functional or Late
• Electrolyte and Fluid Balance Conditions

Interventions

Type	Name	Description
DRUG	81 mg enteric coated aspirin	81 mg enteric coated aspirin will be provided both as an acute dosage immediately prior to firefighting (1 hour pre-activity) and as a 14 day dosage prior to firefighting

Timeline

• Start date: 2011-02-01
• Primary completion: 2011-10-01
• Completion: 2012-12-01
• First posted: 2011-01-13
• Last updated: 2020-07-21

Locations

1 site across 1 country: United States