NCT01273818

Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair

Is Topical Antibiotic Prophylaxis Effective in Lichtenstein Hernia Repair: a Comparison Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 276 (actual)
• Sponsor: Diskapi Teaching and Research Hospital · Academic / Other
• Sex: All
• Age: 16 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Aim of this study is to measure the effectiveness of topical gentamicin to prevent post-operative infection in inguinal tension-free hernia repair operation.Secondary aim is, if it is effective as a prophylactic agent, to compare it's effect with intra venous single dose cefazolin sodium prophylaxis.

Detailed description

This study is a single blind prospective randomized trial. To measure and compare the effectiveness intra-operative topical gentamicin application in tension-free inguinal hernia repair in contrast to intravenous peri-operative prophylactic cefazolin sodium and combination of gentamicin and cephazolin this study is designed. The patients are grouped randomly in to two groups: * Group1;intravenous cefazolin sodium * Group2;topical gentamicin * Group3:topical gentamicin and intravenous cefazolin sodium As a control group we decided to use the data of control groups ( without any prophylactic agent usage ) of previous studies done in our clinic and medical data base reviews.

Conditions

• Inguinal Hernia

Interventions

Type	Name	Description
DRUG	Gentamicin and cefazolin	80 mg topically, intra-operative,single dose and intravenous 1000 mg cefazolin 1 hour before operation
DRUG	Cefazolin	1000 mg cefazolin application intravenously 1 hour before operation
DRUG	Gentamicin	80 mg gentamicin application intraoperatively

Timeline

• Start date: 2011-01-01
• Primary completion: 2013-02-01
• Completion: 2013-03-01
• First posted: 2011-01-11
• Last updated: 2014-12-29
• Results posted: 2014-12-29

Locations

1 site across 1 country: Turkey (Türkiye)