NCT01270854

Normal Saline Versus Plasmalyte in Initial Resuscitation of Trauma Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether an intravenous salt solution called "Plasmalyte" causes less abnormality of the body's acid levels than a solution called "Normal Saline."

Detailed description

Electrolyte-containing intravenous fluids are routinely administered to patients in the first few hours after acute traumatic injury. Although Normal Saline (0.9% sodium chloride) is commonly used in this setting, it causes a hyperchloremic acidosis that may exacerbate metabolic derangements that occur after acute injury. Plasmalyte A is a solution that more closely matches physiologic electrolyte levels. In this study, we will evaluate whether Plasmalyte A results in less disturbance of the base deficit 24 hours following traumatic injury than does Normal Saline.

Conditions

• Wounds and Injuries
• Multiple Trauma
• Disorder of Fluid Balance

Interventions

Type	Name	Description
OTHER	Plasmalyte A	Intravenous fluid
OTHER	Normal Saline	Intravenous fluid

Timeline

• Start date: 2011-02-01
• Primary completion: 2012-02-01
• Completion: 2012-04-01
• First posted: 2011-01-05
• Last updated: 2017-05-30

Locations

1 site across 1 country: United States