NCT01267916

Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity

Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity. Influence of Low Respiratory Rate With Unchanged Minute Volume.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Seoul Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Detailed description

Impaired gas exchange is a common anesthetic problem in obese subjects. It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEPi) is present in grossly obese subjects especially in the supine position. It is known that there is a significant negative correlation between PEEPi present and PaO2. Therefore, the investigators postulated that if the reduce the PEEPi by reducing the respiratory rate in obese subjects, the impaired gas exchange might improve. The investigators tried to research the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Conditions

• General Anesthesia
• Laparoscopic Cholecystectomy

Interventions

Type	Name	Description
DEVICE	RR 6 + 0	Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 0
DEVICE	RR 10 + 0	Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 0
DEVICE	RR 16 + 0	Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 0
DEVICE	RR 6 + 5	Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 5
DEVICE	RR 10 + 5	Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 5
DEVICE	RR 16 + 5	Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 5

Timeline

• Start date: 2011-01-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2010-12-29
• Last updated: 2012-01-31

Locations

1 site across 1 country: South Korea