NCT01267461

Evaluation of the Proliferative Activities of Insulin Analogues in Primary Human Tumor Cells

• Status: Available
• Phase: —
• Study type: Expanded Access
• Enrollment: —
• Sponsor: Meir Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years – 90 Years
• Healthy volunteers: —

Summary

Recently the general medical literature has become aware that the use of certain long-acting insulin analogues could potentially increase cancer risk.During the last few years the investigators group generated information of both scientific and clinical relevance on the proliferative and anti-apoptotic actions of insulin analogues. The goal of this project is to evaluate the hypothesis that the proliferative and signalling activities elicited by insulin analogues may have a impact on tumor behavior. In this study the investigators will asses the biological actions of insulin analogs in primary tumor cells of endometrial and colon cancer.

Conditions

• Endometrial Cancer
• Colon Cancer

Interventions

Type	Name	Description
OTHER	Tissue sample from tumor	Endometrial cancer specimens will be obtained from patients operated and treated at the Gynecologic Oncology Unit at Meir Medical Center. Colon cancer specimens will be obtained from patients that underwent colonoscopy at the Gastrointestinal Department at Meir Medical Center.

Timeline

• First posted: 2010-12-28
• Last updated: 2012-08-10