NCT01264471

Mechanisms of Mitochondrial Defects in Gulf War Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 26 (actual)
• Sponsor: Medical Neurogenetics, LLC · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to investigate possible causes for Gulf War Syndrome. Gulf War Syndrome is associated with increased incidences of amyotrophic lateral sclerosis (Lou Gehrig's Disease), pain syndromes, muscle complaints that include fatigue and myalgias (muscle pain), as well as other neurological symptoms. Abnormalities in the part of the cell known as mitochondria have been delineated in Gulf War Syndrome. Mitochondria are the "power plants" of the body. Mitochondria take the food you eat and break the food down into a form of energy that the body can use. The investigators propose that Gulf War Syndrome is determined by a complex interaction of factors that interfere with mitochondrial function. This study will be the first investigation of mitochondrial function in Gulf War Syndrome. The investigators objective is to establish the cause for symptoms in affected veterans, develop testing that can more easily identify Gulf War Syndrome, and ultimately develop treatment protocols for Gulf War Syndrome.

Conditions

• Gulf War Syndrome
• Mitochondrial Disease

Interventions

Type	Name	Description
PROCEDURE	Skin biopsy	A small skin sample will be obtained from the patients arm which is approximately the size of the top of a thumbtack (a small circle no more than a 1/4 inch across)
PROCEDURE	Blood Collection	Approximately 45ml or 3 tablespoons for blood will be drawn from a vein in the patient's forearm.

Timeline

• Start date: 2009-05-01
• Primary completion: 2013-06-01
• Completion: 2013-06-01
• First posted: 2010-12-21
• Last updated: 2015-04-13

Locations

1 site across 1 country: United States