NCT01261078

The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine

The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine for Spinal Anesthesia in Total Knee Replacement Arthroplasty

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Seoul Medical Center · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Intrathecal epinephrine has been known to increase the duration of spinal anesthesia, or increase the quality of anesthesia. However, there is still a controversy, and the mechanism of epinephrine is recently suggested as a modulator of pain information in the spinal cord. Therefore, the investigators try to investigate the dose sparing effect of intrathecal epinephrine for spinal anesthesia with bupivacaine.

Detailed description

For patient undergoing total knee replacement arthroplasty, patients injected intrathecally with bupivacaine 8 mg were compared with those with bupivacaine 8 mg with 25 mcg of epinephrine, bupivacaine 8 mg with 50 mcg of epinephrine, and those with bupivacaine 8 mg with 100 mcg of epinephrine. The investigators compared the characteristics of spinal anesthesia including the quality and complication of spinal anesthesia. The researchers investigated whether intrathecal dose of epinephrine can reduce bupivacaine requirement and this effect is dependent on the dose of epinephrine.

Conditions

• Spinal Anesthesia

Interventions

Type	Name	Description
DRUG	Placebo	intrathecal 8 mg of bupivacaine only
DRUG	epinephrine 25	intrathecal 8 mg of bupivacaine mixed with 25 mcg of epinephrine
DRUG	Epinephrine 50	intrathecal 8 mg of bupivacaine mixed with 50 mcg of epinephrine
DRUG	epinephrine 100	intrathecal 8 mg of bupivacaine mixed with 0.1 mg of epinephrine
DRUG	Epi 200	intrathecal bupivacaine 8 mg with 200 mcg of epinephrine

Timeline

• Start date: 2010-12-01
• Primary completion: 2011-07-01
• Completion: 2011-07-01
• First posted: 2010-12-16
• Last updated: 2011-07-20

Locations

1 site across 1 country: South Korea