NCT01259648

Study Evaluating the Efficacy and Safety of Remifentanil in a Rapid Sequence Induction for Fragile Subjects

Randomized Study Evaluating the Efficacy and Safety of Remifentanil in a Rapid Sequence Induction for Fragile Subjects

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 65 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The primary objective is to determine whether, during a rapid sequence intubation by etomidate, and succinylcholine Sellick maneuver, the administration of remifentanil at 2 different dosages (0.5 and 1.0 microgram per kg body weight), reduces potentially dangerous reactional tachycardia.

Conditions

• Tachycardia

Interventions

Type	Name	Description
DRUG	0.5 µg/kg remifentanil	0.5 µg/kg remifentanil is used during induction in addition to the classic induction protocol
DRUG	1.0 µg/kg remifentanil	1.0 µg/kg remifentanil is added to the classic induction anesthesia protocol
DRUG	NaCl	an equivalent volume (1 ml for 10 kg of weight) of 0.9% isotonic NaCl is injected in addition to the classic anesthesia induction protocol

Timeline

• Start date: 2011-03-09
• Primary completion: 2014-05-20
• Completion: 2014-05-20
• First posted: 2010-12-14
• Last updated: 2025-11-17

Locations

2 sites across 1 country: France