NCT01248338

Effects of Nebivolol Versus Metoprolol Succinate on Endothelial Function

Comparison the Effects of Nebivolol Versus Metoprolol Succinate on Endothelial Function and Large Artery Stiffness

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Berlin-Chemie AG Menarini Group · Industry
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

An impairment of endothelial function plays the central role in the pathogenesis of cardiovascular diseases and their complications. Most of cardiovascular risk factors are known to impair endothelial function and the established disease further aggravates endothelial dysfunction. The aim of the present study is to investigate the effects of nebivolol or metoprolol succinate on endothelial function and large artery stiffness.

Detailed description

The aim of this study was to compare the effects between the vasodilating β-blocker nebivolol and the cardioselective β-blocker metoprolol succinate on aortic blood pressure and left ventricular wall thickness. We conducted a randomized, double-blind study in 80 hypertensive patients. Patients received either nebivolol 5 mg or metoprolol succinate 50-100 mg daily for one year. Their heart rate, central and brachial blood pressure, mean arterial pressure, augmentation index, carotid-femoral pulse wave velocity and left ventricular wall thickness were measured at baseline and at the end of the study.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	metoprolol succinate	once daily 50 or 100 mg for one year
DRUG	Nebivolol	once daily 5 mg capsule for one year

Timeline

• Start date: 2006-03-01
• Primary completion: 2008-12-01
• Completion: 2009-12-01
• First posted: 2010-11-25
• Last updated: 2010-11-25

Locations

1 site across 1 country: Estonia