NCT01244802

Characterization of Human Memory Immune Responses to Prior Yellow Fever Vaccination

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Emory University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to study immune memory generated against the yellow fever (YFV) vaccine in participants who have previously received the vaccine. Volunteers will not receive vaccine shots; only immune responses to previous yellow fever vaccination will be studied. The study involves one or multiple blood draws.

Detailed description

The goal of this study is to characterize immune memory in humans who have previously received yellow fever vaccine. The project is designed to study the magnitude and persistence of both humoral, and cell-mediated immune memory generated post-vaccination. Since aging has an effect on the immune system (eg. decreased thymic output, replacement of hematopoietic cells in the bone marrow with adipocytes), the researchers will analyze the young adults (aged 18-45 years) and the older vaccinees (55 years or older) in separate groups. The specific aims of the study are to: * Determine the phenotypic and functional characterization of memory T cell responses to yellow fever vaccination * Determine neutralizing antibody titer after yellow fever vaccination

Conditions

• Yellow Fever Vaccine

Timeline

• Start date: 2010-11-01
• Primary completion: 2029-10-01
• Completion: 2029-10-01
• First posted: 2010-11-19
• Last updated: 2024-11-04

Locations

1 site across 1 country: United States