NCT01244204

Role of Vitamin D in Innate Immunity to Tuberculosis

Vitamin D Supplementations as Adjunct to Anti-tuberculosis Drugs in Mongolia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Harvard School of Public Health (HSPH) · Academic / Other
• Sex: All
• Age: 10 Years – 18 Years
• Healthy volunteers: Accepted

Summary

The investigators proposed a pilot study preparatory to developing a randomized trial of vitamin D for the prevention of TB infection. The specific aims are presented below: 1. To recruit subjects, obtain consent, distribute vitamin D supplements to the children in the schools, obtain blood samples and transport them to the United States. 2. To test the hypothesis that daily vitamin D supplementation will increase plasma levels of 25(OH)D, and restore TLR-induced antimicrobial activity in monocytes/macrophages tested in vitro.

Conditions

• Vitamin D Deficiency
• Tuberculosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin D	Daily dose of 800IU of vitamin D
DIETARY_SUPPLEMENT	Placebo	Identically appearing capsules

Timeline

• Start date: 2009-11-01
• Primary completion: 2010-05-01
• Completion: 2011-03-01
• First posted: 2010-11-19
• Last updated: 2012-08-03