NCT01244048

Intervention With n3 LC-PUFA-supplemented Yogurt

Intervention With n3 LC-PUFA-supplemented Yogurt: Effects on Cardiovascular Risk Factors and Inflammatory Biomarkers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: University of Jena · Academic / Other
• Sex: All
• Age: 25 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The effective dosage of a n3-LC-PUFA intervention (with n3 LC-PUFA-enriched yoghurt) on the modulation of cardiovascular risk factors and inflammatory biomarkers were determined.

Detailed description

Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 150 mg/dL (1.7 mmol/L)) participated on the placebo-controlled, double-blind, parallel designed study. The subjects consumed placebo yoghurt (1), or n3 LC-PUFA-enriched yoghurt (0.8 g n3 LC-PUFA/d (2), 3 g n3 LC-PUFA/d (3)) for 10 weeks. Blood samples were taken at the beginning and at the end of the period. Parameters: * Blood lipids (total cholesterol, HDL, LDL, triacylglycerols) * Fatty acid distribution of plasma lipids (PL) and erythrocyte membranes (EM) * Concentrations of eicosanoids (PGs, HETEs) * Production of ex vivo stimulated cytokines by T cells * SNPs in the CD36 genotype

Conditions

• Moderate Hypertriacylglycerolemic Subjects

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	n3 long chain polyunsaturated fatty acids	Group 1 (placebo) Group 2 (0.8 g n3 LC-PUFA/d in 125 g yoghurt) Group 3 (3 g n3 LC-PUFA/d in 200 g yoghurt)

Timeline

• Start date: 2009-02-01
• Primary completion: 2009-04-01
• Completion: 2009-04-01
• First posted: 2010-11-19
• Last updated: 2012-03-07

Locations

1 site across 1 country: Germany