NCT01242332

Perioperative Administration of Pregabalin in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction

Perioperative Administration of Pregabalin in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction: Does it Help to Relieve Postoperative Pain?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Prince of Songkla University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

To prove pregabalin's efficacy and safety in Thai patients scheduled for arthroscopic ACL reconstruction

Detailed description

Only eligible patients with willingness to join this study are included. Eligible patients are those aged 18-65 years of either sex, American Society of Anesthesiologists (ASA) physical status I \& II, and body mass index (BMI) between 16-35. The exclusion criteria are patients who are allergic to pregabalin, with impaired hepatic and renal functions, alcohol or substance abuse, chronic pain (except pain in the knee joint) or daily intake of analgesics, uncontrolled medical disease (hypertension and diabetes mellitus) and inability to operate patient-controlled analgesia (PCA) device. Data analysis * Student t-test for continuous data with normal distribution * Mann-Whitney U test for continuous data with non-normal distribution * Chi-square test for categorical data

Conditions

• Postoperative Pain Management

Interventions

Type	Name	Description
DRUG	Pregabalin	75 mg po 2 hrs before surgery

Timeline

• Start date: 2009-08-01
• Primary completion: 2010-10-01
• Completion: 2010-10-01
• First posted: 2010-11-17
• Last updated: 2010-11-17

Locations

1 site across 1 country: Thailand