NCT01238848

Efficacy of Nebulized Hypertonic Saline in the Treatment of Acute Bronchiolitis

A Randomized Controlled Trial to Evaluate Efficacy of Nebulized Hypertonic Saline vs. Normal Saline in the Treatment of Hospitalized Children With Bronchiolitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: Hospital General de Niños Pedro de Elizalde · Academic / Other
• Sex: All
• Age: 1 Month – 2 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the efficacy of hypertonic saline vs. normal saline in the treatment of infants hospitalized for bronchiolitis, regarding length of hospital stay, oxygen requirements and clinical outcome.

Detailed description

Despite bronchiolitis is a very frequent disease among infants, there are still controversies regarding its treatment. Hypertonic saline has been proposed as useful treatment in these children, bur information is still controversial. The aim is to asses that using Nebulized Hypertonic Saline with bronchodilators (albuterol) may reduce the days of hospitalization and improve clinical outcomes in patients with acute bronchiolitis, compared with using Normal Saline with albuterol.

Conditions

• Bronchiolitis

Interventions

Type	Name	Description
DRUG	Hypertonic saline	3 cc nebulized hypertonic saline + albuterol 0.25 mg/kg/day, four times a day (QID), 5 days
DRUG	Normal saline	3 cc nebulized normal saline + albuterol 0.25 mg/kg/day, four times a day (QID), 5 days

Timeline

• Start date: 2010-12-01
• Primary completion: 2011-10-01
• Completion: 2012-05-01
• First posted: 2010-11-11
• Last updated: 2017-02-10
• Results posted: 2012-08-17

Locations

1 site across 1 country: Argentina