NCT01237431

Importance of Liver Innervation for the Osmopressor Response in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Hannover Medical School · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

In patients with autonomic dysfunction water drinking elicits a pressor response mediated by sympathetic activation. If any, in healthy subjects there is only a slight increase in blood pressure. However, the sympathetic activation is observable by resting energy expenditure increases greater than 20%. The investigators believe that the response to water may be mediated through sympathetic activation elicited by osmosensitve spinal afferents in the liver. Therefore, the investigators want to test water in liver transplant patients who have a denervated liver. Kidney transplant patients serve as control subjects. The investigators hypothesize that the increase in norepinephrine after water drinking is blunted in liver transplant recipients.

Conditions

• PHYSIOLOGICAL PHENOMENA

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	500ml water intake	subjects have to ingest 500ml water within 5 minutes after resting 30 minutes in supine position

Timeline

• Start date: 2009-11-01
• Primary completion: 2011-01-01
• Completion: 2011-01-01
• First posted: 2010-11-09
• Last updated: 2011-02-23

Locations

1 site across 1 country: Germany