NCT01237353

Study of the Ability of Betaine Hydrochloride to Increase Stomach Acid in Healthy Volunteers

Pilot Study Evaluating Gastric Re-acidification Using Betaine Hydrochloride in Healthy Volunteers With Pharmacologically Induced Hypochlorhydria

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years – 59 Years
• Healthy volunteers: Accepted

Summary

In this study the investigators will test a nutritional supplement called betaine hydrochloride to see if it can temporarily increase the stomach acid in healthy volunteers who have decreased stomach acid because they take a medicine called rabeprazole.

Detailed description

Investigators will evaluate the extent and time course of gastric re-acidification after oral betaine HCl in healthy volunteers with pharmacologically-induced hypochlorhydria. After betaine HCl dose, gastric pH will be continuously monitored for 2 hours.

Conditions

• Pharmacodynamic

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	betaine hydrochloride	betaine hydrochloride 1500mg po x 1 on day 5
DRUG	Rabeprazole	rabeprazole po daily x 5 days

Timeline

• Start date: 2011-03-01
• Primary completion: 2011-07-01
• Completion: 2011-07-01
• First posted: 2010-11-09
• Last updated: 2013-07-02
• Results posted: 2013-07-02

Locations

1 site across 1 country: United States